多取代呋喃的合成方法：炔酸酯和 1,3-二羰基化合物的高效加成/氧化环化反应。
Synthetic approach to polysubstituted furans: an efficient addition/oxidative cyclization of alkynoates and 1,3-dicarbonyl compounds.
机构信息
School of Chemistry and Chemical Engineering, South China University of Technology, 381 Wushan Road, Guangzhou 510640, China.
出版信息
J Org Chem. 2010 Feb 5;75(3):966-8. doi: 10.1021/jo902375k.
PMID:20055376
Abstract
A novel and reliable method for the direct construction of polysubstituted furans is reported. The key transformation involves Sn(II)- and Cu(I)-involved addition/oxidative cyclization of alkynoates and 1,3-dicarbonyl compounds in the presence of 2,3-dichloro-5,6-dicyanobenzoquinone.
摘要
本文报道了一种新颖、可靠的构建多取代呋喃的方法。该方法的关键转化是在 2,3-二氯-5,6-二氰基对苯醌存在下，通过锡（II）和铜（I）参与的炔酸酯和 1,3-二羰基化合物的加成/氧化环化反应实现的。
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