铜催化α,β-炔酮与重氮乙酸酯的[4 + 1]环加成反应以形成三取代呋喃。
Copper-catalyzed [4 + 1] cycloadditions of alpha,beta-acetylenic ketones with diazoacetates to form trisubstituted furans.
作者信息
Zhao Lian-Biao, Guan Zheng-Hui, Han Yao, Xie Yong-Xin, He Sheng, Liang Yong-Min
机构信息
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PRC.
出版信息
J Org Chem. 2007 Dec 21;72(26):10276-8. doi: 10.1021/jo7019465. Epub 2007 Nov 28.
PMID:18041850
Abstract
Copper-catalyzed [4 + 1] cycloaddition reaction of alpha,beta-acetylenic ketones with alpha-diazo esters offers an efficient, direct route to highly substituted furans. The reaction conditions and the scope of the process are examined, and a possible mechanism is proposed.
摘要
铜催化的α,β-炔酮与α-重氮酯的[4 + 1]环加成反应为合成高度取代的呋喃提供了一条高效、直接的途径。本文考察了该反应的条件和适用范围，并提出了一种可能的反应机理。
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