丙戊酸盐治疗新诊断的特发性全面性癫痫儿童。
Valproate in children with newly diagnosed idiopathic generalized epilepsy.
机构信息
Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
出版信息
Acta Neurol Scand. 2010 Mar;121(3):149-53. doi: 10.1111/j.1600-0404.2009.01308.x. Epub 2010 Jan 6.
Abstract
OBJECTIVES
Sparse information on dose-response characteristics for initial antiepileptic drug monotherapy in children with idiopathic generalized epilepsy (IGE) is available. The aim of this study is to characterize the therapeutic dose of valproate in children with newly diagnosed IGE.
MATERIALS AND METHODS
Effect of initial valproate monotherapy and doses associated with seizure freedom were examined in consecutive children with IGE identified from a New Onset Seizure Clinic.
RESULTS
Of 84 patients identified, 48 (57%) became seizure-free on valproate monotherapy and another 10 patients became seizure-free but discontinued VPA because of adverse effects. The mean dose in seizure-free children was 15.7 mg/kg/day and over 95% of IGE patients will respond below 25 mg/kg/day.
CONCLUSIONS
Half of children became seizure-free on valproate monotherapy and did so at modest doses.
摘要
目的
关于特发性全面性癫痫（IGE）儿童初始抗癫痫药物单药治疗的剂量-反应特征的信息很少。本研究旨在确定新诊断为 IGE 的儿童中丙戊酸钠的治疗剂量。
材料和方法
从新发病例癫痫诊所中连续确定的 IGE 患儿中，研究了初始丙戊酸钠单药治疗的效果以及与无癫痫发作相关的剂量。
结果
在确定的 84 例患者中，48 例（57%）在丙戊酸钠单药治疗后无癫痫发作，另有 10 例因不良反应而无癫痫发作但停用丙戊酸钠。无癫痫发作患儿的平均剂量为 15.7mg/kg/天，超过 95%的 IGE 患者在 25mg/kg/天以下会有反应。
结论
一半的儿童在丙戊酸钠单药治疗下无癫痫发作，且剂量适中。
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