Department of Psychiatry and Psychotherapy, University of Jena, Germany.
Psychol Med. 2010 Nov;40(11):1879-86. doi: 10.1017/S0033291709991930. Epub 2010 Jan 8.
With regard to current neurobiological theories, the aim of our study was to examine possible alterations of temporal and frontal lobe volume in panic disorder (PD).
Seventeen in-patients with PD and a group of healthy control subjects (HC) matched for age and gender were investigated by quantitative volumetric magnetic resonance imaging (MRI). Structures of interest were: the temporal lobe, the amygdala-hippocampus complex (AHC) and the frontal lobe. In addition, a voxel-based morphometry (VBM) analysis implemented in Statistical Parametric Mapping 5 (SPM5) was used for a more detailed assessment of possible volume alterations. Modulated grey matter (GM) images were used to test our a priori hypotheses and to present the volumetric results.
Quantitative volumetric MRI revealed a bilateral reduction in temporal lobe volume in patients with PD compared to HC subjects. The AHC was normal. The right frontal lobe volume was also decreased. Using VBM we detected a significant GM volume reduction in the right middle temporal gyrus [Brodmann area (BA) 21] in patients with PD. In addition, there was a reduction in GM volume in the medial part of the orbitofrontal cortex (BA 11).
Our results of reduced temporal and frontal lobe volume in PD are in agreement with prior studies. By using a recent VBM approach we were able to assess the abnormalities more precisely. The location of GM volume reduction in the right middle temporal gyrus and medial orbitofrontal cortex lends further support to recent aetiological models of PD.
根据当前神经生物学理论，我们的研究旨在探讨惊恐障碍（PD）患者颞叶和额叶体积的可能变化。
对 17 例 PD 住院患者和一组年龄和性别匹配的健康对照组（HC）进行定量容积磁共振成像（MRI）检查。感兴趣的结构包括：颞叶、杏仁核-海马复合体（AHC）和额叶。此外，还使用统计参数映射 5（SPM5）中的基于体素的形态测量学（VBM）分析来更详细地评估可能的体积变化。调制灰质（GM）图像用于检验我们的先验假设并呈现体积结果。
定量容积 MRI 显示 PD 患者的双侧颞叶体积较 HC 受试者减少。AHC 正常。右侧额叶体积也减少了。使用 VBM，我们在 PD 患者的右侧颞中回[布罗德曼区（BA）21]中检测到 GM 体积的显著减少。此外，眶额皮质内侧部分（BA 11）的 GM 体积也减少了。
我们在 PD 中观察到颞叶和额叶体积减少的结果与先前的研究一致。通过使用最近的 VBM 方法，我们能够更精确地评估异常情况。GM 体积减少的位置在右侧颞中回和内侧眶额皮质，进一步支持 PD 的近期病因模型。
