Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, NG7 2RD, UK.
Neuroimage. 2010 May 15;51(1):274-9. doi: 10.1016/j.neuroimage.2009.12.113. Epub 2010 Jan 4.
Mapping cerebrovascular reactivity (CVR) to hypercapnia is important both clinically and for improved understanding of the haemodynamic properties of the BOLD effect. In this work, BOLD/R2 CVR was investigated by using a device which provided small, repeatable and stable steps in PETCO2, whilst maintaining a steady PETO2 level. Significant CVR was observed in both grey and white matter at both 3 and 7 T, whilst an approximately linear relationship found between R2 CVR and field strength has implications for BOLD models and calibration. Grey matter R2 CVR was 0.066+/-0.004 s(-1) mm Hg(-1) at 3 T and 0.141+/-0.008 s(-1) mm Hg(-1) at 7 T. White matter R2 CVR was 0.021+/-0.003 s(-1) mm Hg(-1) at 3 T and 0.040+/-0.007 s(-1) mm Hg(-1) at 7 T.
对脑血管反应性（CVR）进行映射对于临床应用和深入了解 BOLD 效应的血液动力学特性都非常重要。在这项工作中，通过使用一种设备来研究 BOLD/R2 CVR，该设备可在保持 PETO2 水平稳定的同时提供小的、可重复的和稳定的 PETCO2 阶跃。在 3T 和 7T 时，灰质和白质中都观察到了显著的 CVR，而 R2 CVR 与场强之间的近似线性关系对 BOLD 模型和校准具有重要意义。灰质 R2 CVR 在 3T 时为 0.066+/-0.004 s(-1) mm Hg(-1)，在 7T 时为 0.141+/-0.008 s(-1) mm Hg(-1)。白质 R2 CVR 在 3T 时为 0.021+/-0.003 s(-1) mm Hg(-1)，在 7T 时为 0.040+/-0.007 s(-1) mm Hg(-1)。
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