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阿仑膦酸钠在缓解围绝经期骨丢失中的作用:一项双盲随机对照初步研究。

The role of alendronate in mitigating perimenopausal bone loss: a double-blind randomized controlled pilot study.

机构信息

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California, USA.

出版信息

Fertil Steril. 2010 Aug;94(3):1138-40. doi: 10.1016/j.fertnstert.2009.11.030. Epub 2010 Jan 8.

DOI:10.1016/j.fertnstert.2009.11.030
PMID:20056199
Abstract

Compared with placebo, alendronate treatment resulted in a significant protection against bone loss in healthy perimenopausal women. This protection occurred at both the spine and the hip and was evident after 6 months of therapy.

摘要

与安慰剂相比,阿伦膦酸钠治疗可显著预防健康绝经前妇女的骨质流失。这种保护作用发生在脊柱和臀部,并且在治疗 6 个月后就很明显。

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[Alendronate in postmenopausal women with osteopenia and osteoporosis: effects on bone mineral density during treatment and after withdrawal].[阿仑膦酸钠对绝经后骨质减少和骨质疏松症女性的影响:治疗期间及停药后的骨密度变化]
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Alendronate prevents loss of bone density associated with discontinuation of hormone replacement therapy: a randomized controlled trial.阿仑膦酸盐可预防与激素替代疗法停用相关的骨密度丢失:一项随机对照试验。
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Bisphosphonates Preserve Bone Mineral Density and Suppress Bone Turnover Markers in Early Menopausal Women: A Systematic Review and Meta-Analysis of Randomized Trials.双膦酸盐可维持绝经早期女性的骨矿物质密度并抑制骨转换标志物:一项随机试验的系统评价和荟萃分析
JBMR Plus. 2023 Apr 14;7(6):e10748. doi: 10.1002/jbm4.10748. eCollection 2023 Jun.