Yatscoff R W, Wayne E A, Tenenbein M
Department of Clinical Chemistry, University of Manitoba, Winnipeg.
J Toxicol Clin Toxicol. 1991;29(1):1-10. doi: 10.3109/15563659109038592.
The criteria for the cessation of deferoxamine therapy in the acutely iron poisoned patient are vague and imprecise. We have developed a urinary iron assay which is not confounded by the presence of deferoxamine and have established a reference range in non-iron poisoned deferoxamine treated human volunteers. When reported as a urine iron to creatinine ratio the results from isolated urine specimens can be utilized to guide deferoxamine therapy. This method is rapid, simple and inexpensive and utilizes equipment and reagents found in laboratories already providing emergency serum iron concentrations. We have found this assay to be useful as a criterion for the cessation of deferoxamine therapy in the acutely iron poisoned patient and as an objective indicator of a positive deferoxamine chelation challenge.
对于急性铁中毒患者停止去铁胺治疗的标准尚不明确且不精确。我们开发了一种不受去铁胺存在干扰的尿铁检测方法，并在未患铁中毒且接受去铁胺治疗的人类志愿者中建立了参考范围。当以尿铁与肌酐比值报告时，来自单独尿液标本的结果可用于指导去铁胺治疗。该方法快速、简单且成本低廉，使用的设备和试剂在已能提供急诊血清铁浓度的实验室中即可找到。我们发现该检测方法对于确定急性铁中毒患者停止去铁胺治疗的时机很有用，并且是去铁胺螯合激发试验阳性的客观指标。
