Bauer P, Maire B, Weber M, Bollaert P E, Larcan A, Lambert H
Department of Intensive Care Unit, University Hospital, Hôpital Central, Nancy, France.
J Toxicol Clin Toxicol. 1991;29(1):23-30. doi: 10.3109/15563659109038594.
The nonfatal case of a 20 year-old woman who ingested 6 grams of chloroquine in a suicide attempt is reported. After initial ventricular fibrillation, she rapidly developed a pulmonary edema with cardiogenic shock. She was successfully treated with diazepam, epinephrine, dobutamine and mechanical ventilation. Plasma chloroquine levels showed an initial peak of 36 micrograms/mL. The patient was discharged fully recovered after 19 days. The interaction between chloroquine and diazepam is discussed, as is the need for careful management of epinephrine therapy.
报告了一名20岁女性自杀未遂摄入6克氯喹的非致命病例。最初出现心室颤动后,她迅速发展为伴有心源性休克的肺水肿。她接受了地西泮、肾上腺素、多巴酚丁胺和机械通气治疗,最终成功康复。血浆氯喹水平最初峰值为36微克/毫升。患者在19天后完全康复出院。文中讨论了氯喹与地西泮之间的相互作用,以及肾上腺素治疗时谨慎管理的必要性。