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质粒介导的氟苯尼考和头孢噻肟耐药性由法国患病牛源大肠杆菌分离株中的 floR 和 blaCMY-2 基因编码。

Plasmid-borne florfenicol and ceftiofur resistance encoded by the floR and blaCMY-2 genes in Escherichia coli isolates from diseased cattle in France.

机构信息

Agence Française de SécuritéSanitaire des Aliments, Unité Antibiorésistance et VirulenceBactériennes, 31 avenue Tony Garnier, 69364 Lyon, France.

Agence Française de SécuritéSanitaire des Aliments, Unité Mycoplasmologie - Bactériologie,BP 53, 22440 Ploufragan, France.

出版信息

J Med Microbiol. 2010 Apr;59(Pt 4):467-471. doi: 10.1099/jmm.0.016162-0. Epub 2010 Jan 7.

DOI:10.1099/jmm.0.016162-0
PMID:20056773
Abstract

This study was designed to determine the genetic basis of florfenicol and ceftiofur resistance in Escherichia coli isolates recovered from French cattle. In these isolates, ceftiofur resistance was conferred by bla(CMY-2) located on three distinct conjugative plasmids on a specific DNA fragment, ISEcp1-bla(CMY-2)-blc- sugE. Two of the plasmids also carried the floR gene conferring resistance to florfenicol. The floR gene was shown to be associated with the insertion sequence ISCR2. Mobile elements appear to contribute to the mobilization of floR and bla(CMY-2) genes in E. coli. The presence of bla(CMY-2) and floR on the same plasmid highlights the potential risk for a co-selection of the bla(CMY-2) gene through the use of florfenicol in food animal production.

摘要

这项研究旨在确定从法国牛群中分离出的对氟苯尼考和头孢噻呋具有耐药性的大肠杆菌的遗传基础。在这些分离物中，头孢噻呋的耐药性由 bla(CMY-2) 基因赋予，该基因位于三个不同的可接合质粒上，位于特定的 DNA 片段 ISEcp1-bla(CMY-2)-blc- sugE 上。其中两个质粒还携带了赋予氟苯尼考耐药性的 floR 基因。研究表明，floR 基因与插入序列 ISCR2 有关。移动元件似乎有助于 floR 和 bla(CMY-2) 基因在大肠杆菌中的转移。bla(CMY-2)和 floR 基因位于同一质粒上，突出表明在食用动物生产中使用氟苯尼考可能会共同选择 bla(CMY-2) 基因。

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