无论是允许性还是非允许性HLA - DPB1错配都能在体内和体外诱导多克隆HLA - DPB1特异性免疫反应。 - Suppr

Both permissive and nonpermissive HLA-DPB1 mismatches can induce polyclonal HLA-DPB1 specific immune responses in vivo and in vitro.

作者信息

Rutten Caroline E, van Luxemburg-Heijs Simone A P, van der Meijden Edith D, Griffioen Marieke, Oudshoorn Machteld, Willemze Roel, Falkenburg J H Frederik

出版信息

Blood. 2010 Jan 7;115(1):151-3. doi: 10.1182/blood-2009-10-249821.

DOI:10.1182/blood-2009-10-249821

PMID:20056799

Abstract

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Both permissive and nonpermissive HLA-DPB1 mismatches can induce polyclonal HLA-DPB1 specific immune responses in vivo and in vitro.无论是允许性还是非允许性HLA - DPB1错配都能在体内和体外诱导多克隆HLA - DPB1特异性免疫反应。

Blood. 2010 Jan 7;115(1):151-3. doi: 10.1182/blood-2009-10-249821.

A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation.由一部分HLA - DPB1等位基因编码的T细胞表位决定了造血干细胞移植的非允许性错配。

Blood. 2004 Feb 15;103(4):1417-24. doi: 10.1182/blood-2003-04-1279. Epub 2003 Oct 23.

Significantly higher frequencies of alloreactive CD4+ T cells responding to nonpermissive than to permissive HLA-DPB1 T-cell epitope disparities.与允许性HLA - DPB1 T细胞表位差异相比，对非允许性HLA - DPB1 T细胞表位差异产生反应的同种异体反应性CD4 + T细胞频率显著更高。

Blood. 2010 Sep 16;116(11):1991-2. doi: 10.1182/blood-2010-05-284687.

HLA-DRB1, -DQB1 and -DPB1 polymorphism in the Slovak population.斯洛伐克人群中HLA - DRB1、- DQB1和 - DPB1基因多态性

Tissue Antigens. 1998 May;51(5):574-6. doi: 10.1111/j.1399-0039.1998.tb02996.x.

Influence of HLA-DPB1 disparity on the development of acute graft-versus-host disease following unrelated donor marrow transplantation.人类白细胞抗原-DPB1差异对无关供者骨髓移植后急性移植物抗宿主病发生的影响。

Transplant Proc. 1993 Feb;25(1 Pt 2):1230-1.

Alloresponses to HLA-DP detected in the primary MLR: correlation with a single amino acid difference.在初次混合淋巴细胞反应中检测到的对HLA-DP的同种异体反应：与单个氨基酸差异的相关性。

Hum Immunol. 1997 Jul;55(2):163-9. doi: 10.1016/s0198-8859(97)00091-8.

HLA-DPB1 mismatching results in the generation of a full repertoire of HLA-DPB1-specific CD4+ T cell responses showing immunogenicity of all HLA-DPB1 alleles.HLA-DPB1 错配导致 HLA-DPB1 特异性 CD4+ T 细胞反应的全套产生，显示所有 HLA-DPB1 等位基因的免疫原性。

Biol Blood Marrow Transplant. 2010 Sep;16(9):1282-92. doi: 10.1016/j.bbmt.2010.03.018. Epub 2010 Mar 27.

Permissive, nonpermissive HLA-DPB1 epitope disparities and the specificity of T cells infiltrating the skin during acute graft-versus-host disease.急性移植物抗宿主病期间，允许性、非允许性HLA-DPB1表位差异及浸润皮肤的T细胞特异性

Blood. 2011 May 26;117(21):5779-81. doi: 10.1182/blood-2011-02-338533.

Allorecognition of HLA-DP by CD4+ T cells is affected by polymorphism in its alpha chain.CD4+ T 细胞对 HLA-DP 的同种异体识别受其α链多态性的影响。

Mol Immunol. 2014 May;59(1):19-29. doi: 10.1016/j.molimm.2013.12.006. Epub 2014 Jan 22.

Frequency of HLA-DPB1 alleles, including a novel DPB1 sequence, in the Northern Ireland population.北爱尔兰人群中HLA-DPB1等位基因的频率，包括一种新的DPB1序列。

Hum Immunol. 1992 Apr;33(4):235-42. doi: 10.1016/0198-8859(92)90330-p.

引用本文的文献

HLA-DPB1 Reactive T Cell Receptors for Adoptive Immunotherapy in Allogeneic Stem Cell Transplantation.HLA-DPB1 反应性 T 细胞受体用于异基因造血干细胞移植中的过继免疫治疗。

Cells. 2020 May 20;9(5):1264. doi: 10.3390/cells9051264.

The allogeneic HLA-DP-restricted T-cell repertoire provoked by allogeneic dendritic cells contains T cells that show restricted recognition of hematopoietic cells including primary malignant cells.同种异体树突状细胞引发的同种异体 HLA-DP 限制性 T 细胞库包含了 T 细胞，这些 T 细胞对包括原发性恶性细胞在内的造血细胞具有受限的识别能力。

Haematologica. 2019 Jan;104(1):197-206. doi: 10.3324/haematol.2018.193680. Epub 2018 Sep 20.

Effect of nonpermissive HLA-DPB1 mismatches after unrelated allogeneic transplantation with in vivo T-cell depletion.非受者 HLA-DPB1 错配对体外 T 细胞耗竭的无关异基因移植后的影响。

Blood. 2018 Mar 15;131(11):1248-1257. doi: 10.1182/blood-2017-07-798751. Epub 2018 Jan 31.

Directionality of non-permissive HLA-DPB1 T-cell epitope group mismatches does not improve clinical risk stratification in 8/8 matched unrelated donor hematopoietic cell transplantation.非相容 HLA-DPB1 T 细胞表位组错配的方向性不能改善 8/8 匹配的无关供者造血细胞移植中的临床风险分层。

Bone Marrow Transplant. 2017 Sep;52(9):1280-1287. doi: 10.1038/bmt.2017.96. Epub 2017 Jun 5.

HLA-DPB1 mismatch alleles represent powerful leukemia rejection antigens in CD4 T-cell immunotherapy after allogeneic stem-cell transplantation.HLA-DPB1 错配等位基因是异基因造血干细胞移植后 CD4 T 细胞免疫治疗中强有力的白血病排斥抗原。

Leukemia. 2017 Feb;31(2):434-445. doi: 10.1038/leu.2016.210. Epub 2016 Aug 1.

High HLA-DP Expression and Graft-versus-Host Disease.高HLA-DP表达与移植物抗宿主病

N Engl J Med. 2015 Aug 13;373(7):599-609. doi: 10.1056/NEJMoa1500140.

In a 12-allele analysis HLA-DPB1 matching is associated with improved OS in leukaemic and myelodysplastic patients receiving myeloablative T-cell-depleted PBSCT from unrelated donors.在一项包含 12 个等位基因的分析中，HLA-DPB1 匹配与接受非亲缘供体去T 细胞清除性 PBSCT 的白血病和骨髓增生异常患者的 OS 改善相关。

Bone Marrow Transplant. 2014 May;49(5):657-63. doi: 10.1038/bmt.2014.8. Epub 2014 Feb 17.

Multiple mismatches at the low expression HLA loci DP, DQ, and DRB3/4/5 associate with adverse outcomes in hematopoietic stem cell transplantation.低表达 HLA 基因座 DP、DQ 和 DRB3/4/5 上的多个错配与造血干细胞移植的不良结局相关。

Blood. 2013 May 30;121(22):4603-10. doi: 10.1182/blood-2013-02-481945. Epub 2013 Apr 17.

Effect of MHC and non-MHC donor/recipient genetic disparity on the outcome of allogeneic HCT.主要组织相容性复合体（MHC）和非 MHC 供体/受者遗传差异对异基因造血细胞移植结局的影响。

Blood. 2012 Oct 4;120(14):2796-806. doi: 10.1182/blood-2012-04-347286. Epub 2012 Aug 2.

Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study.无关供者造血细胞移植受者 HLA-DPB1 中 T 细胞表位匹配的效果：一项回顾性研究。

Lancet Oncol. 2012 Apr;13(4):366-74. doi: 10.1016/S1470-2045(12)70004-9. Epub 2012 Feb 15.

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Both permissive and nonpermissive HLA-DPB1 mismatches can induce polyclonal HLA-DPB1 specific immune responses in vivo and in vitro.

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