Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm & Carlton St, Buffalo, NY 14263, USA.
Circ Res. 2010 Jan 8;106(1):68-78. doi: 10.1161/CIRCRESAHA.109.207076.
The circadian clock is an evolutionarily conserved time-keeping system that coordinates the physiology of the organism with daily changes in the environment. A growing body of evidence gradually leads to the conception that virtually all aspects of the biochemical, physiological, and behavioral functions of the animal are linked to circadian regulation. Moreover, proper synchronization of various processes through the activity of circadian components is important for the well-being of many organisms, including humans. The focus of this review is the circadian control of an organism's response to genotoxic stress, which is a major contributor to life-threatening human pathologies such as cancer and cardiovascular disease.
生物钟是一种进化上保守的计时系统，它使生物体的生理机能与环境的日常变化相协调。越来越多的证据逐渐表明，动物的几乎所有生化、生理和行为功能都与生物钟调节有关。此外，通过生物钟成分的活动使各种过程得到适当的同步对包括人类在内的许多生物体的健康都很重要。本综述的重点是生物钟对生物体对遗传毒性应激反应的控制，遗传毒性应激是导致危及生命的人类疾病（如癌症和心血管疾病）的主要因素之一。
