阿尔茨海默病：载脂蛋白 E 研究的新进展。
Alzheimer disease: New light on an old CLU.
出版信息
Nat Rev Neurol. 2010 Jan;6(1):11-3. doi: 10.1038/nrneurol.2009.213.
Abstract
Genome-wide association studies (GWAS) have uncovered over two dozen candidate Alzheimer disease susceptibility genes; however, the results of these studies showed limited overlap. Two independently performed GWAS involving cohorts from europe and the US have now identified three additional putative Alzheimer disease genes that show modest but remarkably consistent effects across data sets.
摘要
全基因组关联研究（GWAS）已经发现了二十多个候选阿尔茨海默病易感基因；然而，这些研究的结果显示出有限的重叠。两项独立进行的涉及欧洲和美国队列的 GWAS 现在已经确定了另外三个潜在的阿尔茨海默病基因，这些基因在数据集中表现出适度但非常一致的影响。
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