Department of Anesthesiology, Perioperative Management, and Pain Medicine, University of Miami/Miller School of Medicine.
Ther Clin Risk Manag. 2009;5:949-59. doi: 10.2147/tcrm.s5583. Epub 2009 Dec 29.
Fospropofol, a phosphorylated prodrug version of the popular induction agent propofol, is hydrolyzed in vivo to release active propofol, formaldehyde, and phosphate. Pharmacodynamic studies show fospropofol provides clinically useful sedation and EEG/bispectral index suppression while causing significantly less respiratory depression than propofol. Pain at the injection site, a common complaint with propofol, was not reported with fospropofol; the major patient complaint was transitory perianal itching during the drug's administration. Although many clinicians believe fospropofol can safely be given by a registered nurse, the FDA mandated that fospropofol, like propofol, must be used only in the presence of a trained anesthesia provider.
磷苯丙泊酚是常用诱导剂丙泊酚的磷酸化前药，在体内被水解以释放出活性丙泊酚、甲醛和磷酸盐。药效动力学研究表明，磷苯丙泊酚在提供临床有用镇静作用和脑电图/双频谱指数抑制的同时，比丙泊酚引起的呼吸抑制明显减少。注射部位疼痛是丙泊酚的常见不良反应，但磷苯丙泊酚没有报告；主要的患者抱怨是在药物给药期间短暂的肛周瘙痒。尽管许多临床医生认为注册护士可以安全地给予磷苯丙泊酚，但 FDA 强制规定，像丙泊酚一样，只有在有经过培训的麻醉师在场的情况下才能使用磷苯丙泊酚。
