Houston Center for Quality of Care & Utilization Studies, Health Services Research and Development Service, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA.
Psychiatr Q. 2010 Jun;81(2):97-110. doi: 10.1007/s11126-009-9121-7.
The purpose of this study was to systematically review the literature to determine whether aggression is linked to psychosis in persons with dementia. An electronic search using PubMed for articles in English focusing on psychosis and aggression or agitation in adults aged 65+ with dementia. Cross-sectional, longitudinal, and randomized controlled treatment studies examining the outcomes of aggression and psychosis were eligible for inclusion. Eighteen articles were selected for final analysis. Of the seven cross-sectional and two longitudinal studies directly examining the correlation of aggression and psychosis, most showed a positive association. Outcome data from the nine treatment studies was more mixed. Limited data link psychosis with aggression in persons with dementia. Prospectively designed studies looking at the temporal relationship of these variables are needed to make a stronger causal argument.
本研究旨在系统地回顾文献，以确定痴呆患者的攻击性是否与精神病有关。使用 PubMed 以英文进行电子检索，重点关注 65 岁及以上患有痴呆症的成年人的精神病和攻击性或激越。纳入了研究攻击性和精神病结果的横断面、纵向和随机对照治疗研究。最终分析选择了 18 篇文章。在直接研究攻击性和精神病相关性的七项横断面研究和两项纵向研究中，大多数研究显示出正相关。九项治疗研究的结果数据更为混杂。有限的数据将精神病与痴呆患者的攻击性联系起来。需要前瞻性设计研究来观察这些变量之间的时间关系，以得出更强的因果关系。
