The Chinese University of Hong Kong, Department of Electronic Engineering, Shatin, NT, Hong Kong.
J Biomed Opt. 2009 Nov-Dec;14(6):064017. doi: 10.1117/1.3268439.
We demonstrate how the terahertz properties of porcine adipose tissue and skeletal muscle are affected by formalin fixing. Terahertz radiation is sensitive to covalently cross-linked proteins and can be used to probe unique spectroscopic signatures. We study in detail the changes arising from different fixation times and see that formalin fixing reduces the refractive index and the absorption coefficient of the samples in the terahertz regime. These fundamental properties affect the time-domain terahertz response of the samples and determine the level of image contrast that can be achieved.
我们展示了福尔马林固定如何影响猪的脂肪组织和骨骼肌的太赫兹特性。太赫兹辐射对共价交联的蛋白质很敏感，可以用来探测独特的光谱特征。我们详细研究了不同固定时间引起的变化，发现福尔马林固定降低了太赫兹波段下样品的折射率和吸收系数。这些基本特性会影响样品的太赫兹时域响应，从而决定可以实现的图像对比度水平。
