Department of Thoracic Surgery, University Hospital Gasthuisberg, Leuven, Belgium.
Transpl Int. 2010 Jun;23(6):628-35. doi: 10.1111/j.1432-2277.2009.01033.x. Epub 2010 Jan 5.
Relaxing the standard lung donor criteria may significantly increase the reported 15% organ yield but post-transplant recipient outcome should be carefully monitored. Charts from all consecutive deceased organ donors within our hospital network were reviewed over a 2-year period. Reasons for lung refusals and number of lungs transplanted were analysed. Hospital outcome including early recipient survival was compared between standard- and extended criteria donors. Out of 283 referrals, 164 (58%) qualified as donor of any organ. The majority (65.9%) of these effective donors were declined for lung donation because of chest X-ray abnormalities (20%), age >70 years (13%), poor oxygenation (10%), or aspiration (9%). Out of 56 (34.1%) accepted lung donors, 50 transplants were performed at our center, 23 from standard criteria donors versus 27 from extended criteria donors. There were no significant differences in hospital outcome and in early survival between lung recipients from both donor groups. Lung acceptance rate (34.1%) in our donor network is 10-20% higher than reported figures. The number of lung transplants in our center doubled by accepting extended criteria donors. This policy did not negatively influence our results after lung transplantation.
放宽标准的肺供体标准可能会显著增加报告的 15%的器官供体数量，但应仔细监测移植后受体的结果。在 2 年的时间里，对我们医院网络中所有连续的已故器官供体的图表进行了回顾。分析了肺拒绝的原因和移植的肺数量。比较了标准和扩展标准供体的医院结果，包括早期受者存活率。在 283 例转诊中，164 例（58%）符合任何器官供体的条件。这些有效供体中的大多数（65.9%）因胸片异常（20%）、年龄>70 岁（13%）、氧合差（10%）或误吸（9%）而被拒绝捐献肺。在 56 例（34.1%）接受的肺供体中，有 50 例在我们中心进行了移植，其中 23 例来自标准标准供体，27 例来自扩展标准供体。两组肺受体的医院结果和早期存活率无显著差异。我们的供体网络中的肺接受率（34.1%）比报告的数字高出 10-20%。通过接受扩展标准供体，我们中心的肺移植数量增加了一倍。这项政策并没有对我们的肺移植结果产生负面影响。
