Department of Obstetrics and Gynecology, RAMBAM Health Care Campus and Al-Kol Ultrasound Institute, The Rappaport Institute and the Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Am J Obstet Gynecol. 2010 Apr;202(4):398.e1-4. doi: 10.1016/j.ajog.2009.11.014. Epub 2010 Jan 13.
Report our experience in prenatal diagnosis of 11 cases of interrupted inferior vena cava, summarize the clinical significance and implications of this variant.
Retrospective analysis of 11 fetuses diagnosed with interrupted inferior vena cava, of 55,457 pregnant women who underwent extensive fetal anomaly scan during 20 years.
Eight of the 11 fetuses with interrupted inferior vena cava had a completely normal outcome. One had also normal outcome but abnormal function of the spleen. One had multiple abnormalities, and 1 case was lost to follow up.
The incidence of IIVC is 1:5000. In the vast majority (90%) of the cases, it is an isolated variant not associated with isomerism or fetal anomalies. In all the cases of isolated interrupted inferior vena cava, the outcome is favorable. In 10% of isolated interrupted inferior vena cava, abnormal function of the spleen may be detected after delivery, necessitating antipneumococcal vaccination.
报告我们在 11 例下腔静脉中断产前诊断方面的经验，总结这种变异的临床意义和影响。
回顾性分析 20 年间对 55457 名接受广泛胎儿异常扫描的孕妇中诊断为下腔静脉中断的 11 例胎儿。
11 例下腔静脉中断的胎儿中，8 例完全正常。1 例伴有脾脏功能异常但结局正常。1 例伴有多种异常，1 例失访。
下腔静脉中断的发生率为 1:5000。在绝大多数（90%）病例中，它是一种孤立的变异，与同型或胎儿异常无关。孤立性下腔静脉中断的所有病例结局均良好。在 10%的孤立性下腔静脉中断中，分娩后可能会发现脾脏功能异常，需要接种肺炎球菌疫苗。
