Ringborn Michael, Pettersson Jonas, Persson Eva, Warren Stafford G, Platonov Pyotr, Pahlm Olle, Wagner Galen S
Department of Cardiology, Lund University, Lund, Sweden.
J Electrocardiol. 2010 Mar-Apr;43(2):113-20. doi: 10.1016/j.jelectrocard.2009.11.009. Epub 2010 Jan 8.
This study tests the ability of high-frequency components of the depolarization phase (HF-QRS) vs conventional ST-elevation criteria to detect and quantify myocardial ischemia.
Twenty-one patients admitted for elective percutaneous coronary intervention were included. Quantification of the ischemia was made by myocardial scintigraphy. High-resolution electrocardiogram before and during percutaneous coronary intervention was recorded and signal averaged. The HF-QRS were determined within the frequency band 150 to 250 Hz. ST-segment deviation was measured in the standard frequency range (<100 Hz).
HF-QRS criteria were met by 76% of the patients, whereas 38% met the ST-elevation criteria (P = .008). Both HF-QRS reduction and ST elevation correlated significantly with the amount of ischemia (HF-QRS: r = 0.59, P = .005 for extent and r = 0.69, P = .001 for severity; ST elevation: r = 0.49, P = .023 for extent and r = 0.57, P = .007 for severity).
This study suggests that HF-QRS analysis could provide valuable information both to detect acute ischemia and to quantify myocardial area at risk.
本研究旨在测试去极化期高频成分（HF-QRS）与传统ST段抬高标准在检测和量化心肌缺血方面的能力。
纳入21例因择期经皮冠状动脉介入治疗而入院的患者。通过心肌闪烁显像对缺血进行量化。记录并平均化经皮冠状动脉介入治疗前后的高分辨率心电图。在150至250Hz频段内测定HF-QRS。在标准频率范围（<100Hz）内测量ST段偏移。
76%的患者符合HF-QRS标准，而38%的患者符合ST段抬高标准（P = .008）。HF-QRS降低和ST段抬高均与缺血量显著相关（HF-QRS：范围r = 0.59，P = .005；严重程度r = 0.69，P = .001；ST段抬高：范围r = 0.49，P = .023；严重程度r = 0.57，P = .007）。
本研究表明，HF-QRS分析在检测急性缺血和量化危险心肌面积方面均可提供有价值的信息。
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