麻风病中的先天免疫反应。
The innate immune response in leprosy.
机构信息
Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, CA 90095, USA.
出版信息
Curr Opin Immunol. 2010 Feb;22(1):48-54. doi: 10.1016/j.coi.2009.12.001. Epub 2010 Jan 7.
Abstract
Investigation into the innate immune response in leprosy has provided insight into immunoregulation in human infectious disease. Key advances include the role of pattern recognition receptors in recognizing pathogen-associated molecular patterns of Mycobacterium leprae, cytokine release by innate immune cells, macrophage and dendritic cell differentiation, as well as antimicrobial effector pathways. These insights provide targets for therapeutic intervention in modulating the course of leprosy and other chronic infectious diseases.
摘要
麻风病固有免疫反应的研究为人类感染性疾病的免疫调控提供了新的认识。主要进展包括模式识别受体识别麻风分枝杆菌相关分子模式、固有免疫细胞细胞因子释放、巨噬细胞和树突状细胞分化以及抗菌效应途径的作用。这些新认识为治疗干预麻风病和其他慢性传染病的病程提供了靶点。
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