Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany.
Trends Biochem Sci. 2010 Apr;35(4):220-7. doi: 10.1016/j.tibs.2009.12.001. Epub 2010 Jan 7.
The metabolic network has a modular architecture, is robust to perturbations, and responds to biological stimuli and environmental conditions. Through monitoring by metabolite responsive macromolecules, metabolic pathways interact with the transcriptome and proteome. Whereas pathway interconnecting cofactors and substrates report on the overall state of the network, specialised intermediates measure the activity of individual functional units. Transitions in the network affect many of these regulatory metabolites, facilitating the parallel regulation of the timing and control of diverse biological processes. The metabolic network controls its own balance, chromatin structure and the biosynthesis of molecular cofactors; moreover, metabolic shifts are crucial in the response to oxidative stress and play a regulatory role in cancer.
代谢网络具有模块化的结构，对扰动具有鲁棒性，并对生物刺激和环境条件做出响应。通过代谢物响应大分子的监测，代谢途径与转录组和蛋白质组相互作用。虽然连接途径的辅助因子和底物报告了网络的整体状态，但专门的中间产物则测量了单个功能单元的活性。网络中的转变会影响许多这些调节代谢物，从而促进对不同生物过程的时间和控制的并行调节。代谢网络控制着自身的平衡、染色质结构和分子辅助因子的生物合成；此外，代谢转变在应对氧化应激方面至关重要，并在癌症中发挥调节作用。
