Department of Psychology, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA.
Psychoneuroendocrinology. 2010 Jul;35(6):944-8. doi: 10.1016/j.psyneuen.2009.12.003. Epub 2010 Jan 8.
It is generally established that active-coping strategies and greater perceived control over pain are associated with improved pain-related outcomes; however, it remains unclear whether these factors independently or interactively influence adrenocortical function in reaction to a painful stimulus. The present study examined whether active coping predicted magnitude cortisol response to acute pain, whether perceived control over pain moderated this association, and whether effects differed as a function of sex. Our findings suggest that perceived control moderates the active coping-adrenocortical relation among women but not men, such that active coping may augment the release of cortisol in response to a painful stimulus only in the presence of greater perceived control over pain. Taken together, active coping and perceived control may potentiate an adaptive neuroendocrine response to an acute painful stressor.
一般认为，积极应对策略和对疼痛的更大感知控制与改善疼痛相关结果有关；然而，目前尚不清楚这些因素是否独立或相互作用影响肾上腺皮质功能对疼痛刺激的反应。本研究探讨了积极应对是否预测急性疼痛时皮质醇反应的幅度，疼痛感知控制是否调节这种关联，以及这些效应是否因性别而异。我们的研究结果表明，感知控制调节了女性而非男性的积极应对与肾上腺皮质的关系，即只有在感知控制更大的情况下，积极应对才会增强对疼痛刺激的皮质醇释放。总之，积极应对和感知控制可能增强对急性疼痛应激源的适应性神经内分泌反应。
