European Institute of Oncology, Department of Experimental Oncology, via Adamello 16, 20139 Milan, Italy.
Curr Opin Immunol. 2010 Feb;22(1):131-6. doi: 10.1016/j.coi.2009.12.007. Epub 2010 Jan 8.
Recent advances have highlighted that antigen presentation in the gastrointestinal tract is carried out by different specialized immune and non-immune cells. This is required in order to achieve tolerance towards self and non-self harmless antigens and immunity towards pathogenic microorganisms. In this review we will discuss the role of different players in these responses, including dendritic cells, macrophages, B cells and basophils as professional antigen presenting cells (APCs), and stromal cells and epithelial cells as non-professional APCs. The interaction between these cell types is required for the dynamic regulation of the immune response.
近期的研究进展强调了胃肠道中的抗原呈递是由不同的专门免疫细胞和非免疫细胞完成的。这对于实现对自身和无害的非自身抗原的耐受以及对致病微生物的免疫是必需的。在这篇综述中，我们将讨论不同参与者在这些反应中的作用，包括树突状细胞、巨噬细胞、B 细胞和嗜碱性粒细胞作为专业抗原提呈细胞 (APC)，以及基质细胞和上皮细胞作为非专业 APC。这些细胞类型之间的相互作用对于免疫反应的动态调节是必需的。
