Department of Clinical Radiology, University of Muenster, 48149 Muenster, Germany.
Acad Radiol. 2010 Apr;17(4):427-32. doi: 10.1016/j.acra.2009.11.005. Epub 2010 Jan 12.
This study determines the value of whole brain color-coded three-dimensional perfused blood volume (PBV) computed tomography (CT) for the visualization of the infarcted tissue in acute stroke patients.
Nonenhanced CT (NECT), perfusion CT (PCT), and CT angiography (CTA) in 48 patients with acute ischemic stroke were performed. Whole brain PBV was calculated from NECT and CTA data sets using commercial software. PBV slices in identical orientation to the PCT slices were reconstructed and the area of visual perfusion abnormality on PBV maps was measured. The infarct core in the corresponding PCT slices (CBV <2.0 mL/100 g) was measured automatically with commercial software. The ischemic area on PBV and the infarct core on quantitative PCT were compared using the Pearsons-R correlation coefficient. Significance was considered for P < .05.
The quantitative PCT demonstrated a mean infarct core volume of 35.48 +/- 32.17 cm(3), whereas the volume of visual perfusion abnormality of the corresponding PBV slices was 37.16 +/- 37.59 cm(3). The perfusion abnormality in PBV was highly correlated with the infarct core of quantitative PCT for area per slice (r = 0.933, P < .01) as well as volume (r = 0.922, P < .01).
PBV can serve as surrogate marker corresponding to the infarct core in acute stroke with whole brain coverage.
本研究旨在评估全脑彩色三维血流容积 CT（PBV）在急性脑卒中患者中梗死组织可视化的应用价值。
对 48 例急性缺血性脑卒中患者进行非增强 CT（NECT）、灌注 CT（PCT）和 CT 血管造影（CTA）检查。采用商用软件从 NECT 和 CTA 数据集计算全脑 PBV。重建与 PCT 切片相同方位的 PBV 切片，并测量 PBV 图上的灌注异常面积。采用商用软件自动测量相应 PCT 切片上的梗死核心（CBV <2.0 mL/100 g）。采用 Pearson-R 相关系数比较 PBV 上的缺血区和定量 PCT 上的梗死核心。P <.05 为差异有统计学意义。
定量 PCT 显示平均梗死核心体积为 35.48 +/- 32.17 cm(3)，而相应 PBV 切片的灌注异常体积为 37.16 +/- 37.59 cm(3)。PBV 上的灌注异常与定量 PCT 的梗死核心在每片面积（r = 0.933，P <.01）和体积（r = 0.922，P <.01）上均具有高度相关性。
PBV 可作为急性脑卒中全脑覆盖的梗死核心替代标志物。
