Department of Neurology, Huashan Hospital affiliated to Fudan University, Shanghai, PR China.
Auton Neurosci. 2010 Apr 19;154(1-2):108-11. doi: 10.1016/j.autneu.2009.12.004. Epub 2010 Jan 8.
Urocortin3 (Ucn3) is an endogenous ligand for corticotropin-releasing factor receptor subtype 2 (CRF2R). In this study, we examined its potential cardiovascular effects by microinjection of Ucn3 and anti-sauvagine 30 (ASV30), a selective antagonist of CRF2R, into the paraventricular nucleus (PVN) of the hypothalamus. After Ucn3 (10 pmol/100 nl) was microinjected into the PVN of anesthetized rats, significant increases of systolic blood pressure, heart rate and renal sympathetic nerve activity were observed. Furthermore, all these cardiovascular and autonomic effects induced by Ucn3 could be blocked totally by administration of ASV30 into the PVN. These results are consistent with the idea that Ucn3 might be involved in the central nervous control of cardiovascular function by acting centrally to increase sympathetic outflow via the activation of CRF2R within the PVN.
尿皮质素 3（Ucn3）是促肾上腺皮质素释放因子受体 2（CRF2R）的内源性配体。在这项研究中，我们通过将 Ucn3 和抗 Sauvagine 30（ASV30）（CRF2R 的选择性拮抗剂）注入下丘脑室旁核（PVN），来检测其潜在的心血管效应。在麻醉大鼠的 PVN 中微注射 Ucn3（10 pmol/100 nl）后，观察到收缩压、心率和肾交感神经活性显著增加。此外，通过将 ASV30 注入 PVN，可完全阻断 Ucn3 引起的所有这些心血管和自主神经效应。这些结果与以下观点一致，即 Ucn3 可能通过激活 PVN 内的 CRF2R 来增加交感神经输出，从而参与中枢神经系统对心血管功能的控制。
