Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, California 95616, USA.
Genetics. 2010 Jan;184(1):3-7. doi: 10.1534/genetics.109.110015.
In January 1910, a century ago, Thomas Hunt Morgan discovered his first Drosophila mutant, a white-eyed male (Morgan 1910). Morgan named the mutant gene white and soon demonstrated that it resided on the X chromosome. This was the first localization of a specific gene to a particular chromosome. Thus began Drosophila experimental genetics. The story of the initial work on white is well known but what is less well appreciated is the multiplicity of ways in which this gene has been used to explore fundamental questions in genetics. Here, I review some of the highlights of a century's productive use of white in Drosophila genetics.
1910 年 1 月，也就是一个世纪前，托马斯·亨特·摩根发现了他的第一个果蝇突变体，一个白眼雄性（Morgan 1910）。摩根将这个突变基因命名为 white，并很快证明它位于 X 染色体上。这是第一个将特定基因定位到特定染色体上的例子。由此，果蝇实验遗传学诞生了。关于 white 最初工作的故事广为人知，但人们不太了解的是，这个基因被用来探索遗传学基本问题的多种方式。在这里，我回顾了一个世纪以来在果蝇遗传学中使用 white 的一些突出成果。
