Born Gordian, Bieli Dimi, Metzler Mario, Gohl Daryl M, Affolter Markus, Müller Martin
Biozentrum der Universität Basel, Basel, Switzerland.
Arcondis, Reinach, Switzerland.
MicroPubl Biol. 2023 Apr 5;2023. doi: 10.17912/micropub.biology.000702. eCollection 2023.
Chromatin insulators have been proposed to play an important role in chromosome organization and local regulatory interactions. In , one of these insulators is known as Wari. It is located immediately downstream of the 3' end of the transcription unit. Wari has been proposed to interact with the promoter region, thereby facilitating recycling of the RNA polymerase machinery. We have tested this model by deleting the Wari insulator at the endogenous locus and could not detect a significant effect on eye pigmentation.
染色质绝缘子被认为在染色体组织和局部调控相互作用中发挥重要作用。在[具体情况未提及]中，其中一种绝缘子被称为Wari。它位于转录单元3'端的紧邻下游。有人提出Wari与[具体基因]启动子区域相互作用，从而促进RNA聚合酶机制的循环利用。我们通过在内源[基因名称]位点删除Wari绝缘子来测试该模型，并未检测到对眼色素沉着有显著影响。
