Azarpira Negar, Aghdaie Mahdokht Hosein, Malekpour Zahra
Organ Transplant Research Center, Nemazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Saudi J Kidney Dis Transpl. 2010 Jan;21(1):31-6.
It has been suggested that the serum soluble CD30 (sCD30) level may be a poten-tial marker for the prediction of acute allograft rejection in kidney transplant recipients. Therefore, its serum concentrations might offer a promising non-invasive tool to recognize patients with an increased risk for developing an acute graft rejection. We retrospectively correlate pre and post transplant level on post transplant graft survival, incidence of acute rejection and graft function using stored serum samples. Ninety-nine patients were divided in two separate groups: Group A in whom sample collection was done one day before transplantation and Group B where sample collection was done five days after transplantation. Younger recipients (aged less than 20 years) had higher sCD30 levels (P= 0.02). There was neither significant difference in the incidence of acute rejection nor incomplete response rate after anti rejection therapy in relation to pre transplant or post transplant sCD30. We could not find a significantly inferior graft survival rate in the high sCD30 group. In conclusion, younger patients had higher sCD30 concentrations however no correlation existed between the serum concentrations and occurrence of rejection episodes or graft survival.
有人提出，血清可溶性CD30（sCD30）水平可能是预测肾移植受者急性移植物排斥反应的一个潜在标志物。因此，其血清浓度可能提供一种有前景的非侵入性工具，用于识别发生急性移植物排斥反应风险增加的患者。我们使用储存的血清样本，回顾性地分析了移植前后sCD30水平与移植后移植物存活、急性排斥反应发生率及移植物功能之间的相关性。99例患者被分为两个独立的组：A组在移植前一天采集样本，B组在移植后五天采集样本。年轻受者（年龄小于20岁）的sCD30水平较高（P = 0.02）。急性排斥反应的发生率以及抗排斥治疗后的不完全缓解率，在移植前或移植后的sCD30方面均无显著差异。我们未发现高sCD30组的移植物存活率明显较低。总之，年轻患者的sCD30浓度较高，但血清浓度与排斥反应发作或移植物存活之间不存在相关性。
