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移植前可溶性CD30作为肾移植受者移植肾功能延迟恢复、早期急性排斥反应、长期移植肾功能不良及患者生存的危险因素。

Peritransplant Soluble CD30 as a Risk Factor for Slow Kidney Allograft Function, Early Acute Rejection, Worse Long-Term Allograft Function, and Patients' Survival.

作者信息

Trailin Andriy V, Ostapenko Tetyana I, Nykonenko Tamara N, Nesterenko Svitlana N, Nykonenko Olexandr S

机构信息

Department of Laboratory Diagnostics and General Pathology, State Institution "Zaporizhzhia Medical Academy of Postgraduate Education Ministry of Health of Ukraine", 20 Winter Boulevard, Zaporizhzhia 69096, Ukraine.

Department of Transplantology, Endocrine Surgery and Cardiovascular Surgery, State Institution "Zaporizhzhia Medical Academy of Postgraduate Education Ministry of Health of Ukraine", Zaporizhzhia Regional Hospital, 10 Orikhiv Highway, Zaporizhzhia 69050, Ukraine.

出版信息

Dis Markers. 2017;2017:9264904. doi: 10.1155/2017/9264904. Epub 2017 Jun 11.

DOI:10.1155/2017/9264904
PMID:28694560
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5485490/
Abstract

BACKGROUND

We aimed to determine whether serum soluble CD30 (sCD30) could identify recipients at high risk for unfavorable early and late kidney transplant outcomes.

METHODS

Serum sCD30 was measured on the day of kidney transplantation and on the 4th day posttransplant. We assessed the value of these measurements in predicting delayed graft function, slow graft function (SGF), acute rejection (AR), pyelonephritis, decline of allograft function after 6 months, and graft and patient survival during 5 years of follow-up in 45 recipients.

RESULTS

We found the association between low pretransplant serum levels of sCD30 and SGF. The absence of significant decrease of sCD30 on the 4th day posttransplant was characteristic for SGF, early AR (the 8th day-6 months), late AR (>6 months), and early pyelonephritis (the 8th day-2 months). Lower pretransplant and posttransplant sCD30 predicted worse allograft function at 6 months and 2 years, respectively. Higher pretransplant sCD30 was associated with higher frequency of early AR, and worse patients' survival, but only in the recipients of deceased-donor graft. Pretransplant sCD30 also allowed to differentiate patients with early pyelonephritis and early AR.

CONCLUSIONS

Peritransplant sCD30 is useful in identifying patients at risk for unfavorable early and late transplant outcomes.

摘要

背景

我们旨在确定血清可溶性CD30（sCD30）是否能够识别肾移植受者早期和晚期不良预后的高风险人群。

方法

在肾移植当天及移植后第4天检测血清sCD30。我们评估了这些检测结果在预测45例受者移植肾功能延迟恢复、移植肾功能缓慢恢复（SGF）、急性排斥反应（AR）、肾盂肾炎、6个月后移植肾功能下降以及5年随访期间移植肾和患者生存率方面的价值。

结果

我们发现移植前血清sCD30水平低与SGF之间存在关联。移植后第4天sCD30无显著下降是SGF、早期AR（第8天至6个月）、晚期AR（>6个月）和早期肾盂肾炎（第8天至2个月）的特征。移植前和移植后较低的sCD30分别预测6个月和2年时移植肾功能较差。移植前较高的sCD30与早期AR的较高发生率和较差的患者生存率相关，但仅在尸体供肾移植受者中如此。移植前sCD30还可用于区分早期肾盂肾炎和早期AR患者。

结论

围移植期sCD30有助于识别移植早期和晚期不良预后的风险患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b5/5485490/05329cedaac3/DM2017-9264904.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b5/5485490/2e6c0a2bf7ad/DM2017-9264904.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b5/5485490/6af1cd3afebf/DM2017-9264904.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b5/5485490/6d993ee30f65/DM2017-9264904.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b5/5485490/05329cedaac3/DM2017-9264904.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b5/5485490/2e6c0a2bf7ad/DM2017-9264904.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b5/5485490/6af1cd3afebf/DM2017-9264904.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b5/5485490/6d993ee30f65/DM2017-9264904.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b5/5485490/05329cedaac3/DM2017-9264904.004.jpg

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