Gupta N, Samantaray J C, Duggal S, Srivastava V, Dhull C S, Chaudhary U
Zoonotic Division, National Institute of Communicable Diseases, New Delhi, India.
Indian J Med Microbiol. 2010 Jan-Mar;28(1):67-71. doi: 10.4103/0255-0857.58736.
We report a case of Acanthamoeba keratitis with Curvularia co-infection. Acanthamoeba and fungal co-infection have been uncommonly reported in literature, worldwide. A classical history with a strong clinical suspicion and experienced laboratory personnel with systematic examination of corneal scrapings for bacterial, viral, parasitic and fungal causes are imperative for accurate diagnosis. Early diagnosis of Acanthamoeba keratitis or fungal infection followed by aggressive and appropriate treatment with effective agents is critical for the retention of good vision. Acanthamoeba keratitis is difficult to diagnose and, despite improvement in treatment options, may culminate in prolonged morbidity and significant loss of visual acuity. This case emphasizes the important role played by clinical microbiologists in making prompt diagnosis which can ultimately reduce visual morbidity.
我们报告一例棘阿米巴角膜炎合并弯孢霉菌感染的病例。棘阿米巴与真菌合并感染在全球范围内的文献报道中并不常见。对于准确诊断而言，具有强烈临床怀疑的典型病史以及经验丰富的实验室人员对角膜刮片进行细菌、病毒、寄生虫和真菌病因的系统检查至关重要。早期诊断棘阿米巴角膜炎或真菌感染，随后使用有效药物进行积极且恰当的治疗，对于保留良好视力至关重要。棘阿米巴角膜炎难以诊断，并且尽管治疗方案有所改进，但仍可能导致病程延长和视力显著丧失。该病例强调了临床微生物学家在做出快速诊断中所起的重要作用，这最终可以降低视力损害。
