Kahn R S, Davidson M, Kanof P, McQueeney R T, Singh R R, Davis K L
Mount Sinai Medical Center/Bronx Veterans Administration Hospital, New York.
Psychopharmacology (Berl). 1991;103(1):95-8. doi: 10.1007/BF02244081.
In laboratory animals, prostaglandins have been shown to act as endogenous neuromodulators of central dopamine (DA) activity. To examine the interaction between prostaglandins and DA in man, the effect of a prostaglandin synthesis inhibitor, indomethacin, was studied on plasma concentrations of the DA metabolite, homovanillic acid (pHVA). Indomethacin (150 mg PO) as compared to placebo significantly elevated mean pHVA concentrations in eight normal subjects. Results of this study support the hypothesis that, as in animals, inhibition of prostaglandin synthesis increases central DA turnover in man.
在实验动物中，前列腺素已被证明可作为中枢多巴胺（DA）活性的内源性神经调节剂。为了研究前列腺素与多巴胺在人体中的相互作用，研究了前列腺素合成抑制剂吲哚美辛对多巴胺代谢产物高香草酸（pHVA）血浆浓度的影响。与安慰剂相比，吲哚美辛（口服150毫克）显著提高了8名正常受试者的平均pHVA浓度。这项研究的结果支持了这样的假设，即与动物一样，抑制前列腺素合成会增加人体中枢多巴胺的周转率。
