British Columbia Cancer Agency, University of British Columbia, 600 West 10th Avenue, Rm 3427, Vancouver, BC, V5Z 4E6, Canada.
Fam Cancer. 2010 Sep;9(3):331-4. doi: 10.1007/s10689-009-9316-y.
Hereditary diffuse gastric cancer is an autosomal dominant inherited cancer predisposition syndrome characterized by susceptibility to diffuse gastric and lobular breast cancers. Since current screening options for diffuse gastric cancer are ineffective, prophylactic total gastrectomy (PTG) is a recommended option for unaffected germline CDH1 mutation carriers. It is unknown whether pregnancy after surgery is possible or advisable due to potential maternal nutritional deficiencies. In this report we describe the pregnancy outcomes in three CDH1 mutation positive women after PTG and in a CDH1 mutation negative woman after total gastrectomy for early gastric cancer.
遗传性弥漫性胃癌是一种常染色体显性遗传性癌前倾向综合征，其特征是易患弥漫性胃癌和乳腺小叶癌。由于目前对弥漫性胃癌的筛查方法无效，因此对于未受影响的种系 CDH1 突变携带者，预防性全胃切除术（PTG）是一种推荐的选择。由于潜在的母体营养缺乏，手术后是否可以或是否明智地进行妊娠尚不清楚。在本报告中，我们描述了 3 例 CDH1 突变阳性妇女在 PTG 后和 1 例 CDH1 突变阴性妇女在早期胃癌行全胃切除术后的妊娠结局。
