Leuschner I
Kindertumorregister der Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH), Sektion Kinderpathologie, Institut für Pathologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Michaelisstr. 11, 24105 Kiel.
Pathologe. 2010 Mar;31(2):106-8. doi: 10.1007/s00292-009-1262-9.
Inflammatory myofibroblastic tumor (IMT) is a soft tissue lesion which can be found in almost all parts of the human body, but shows the highest incidence in the abdomen. It is a spindle cell lesion with prominent inflammatory infiltrate which consists predominantly of plasma cells. Using immunohistochemistry a myofibroblastic differentiation can be demonstrated. ALK is expressed in approximately 50% of tumors. The tumors are associated with a benign behavior but recurrences occur in about one third of abdominal cases. Malignant cases are rare.
炎性肌纤维母细胞瘤(IMT)是一种软组织病变,几乎可在人体的所有部位发现,但在腹部的发病率最高。它是一种梭形细胞病变,伴有明显的炎症浸润,主要由浆细胞组成。通过免疫组织化学可证实肌纤维母细胞分化。约50%的肿瘤表达ALK。这些肿瘤通常表现为良性行为,但约三分之一的腹部病例会复发。恶性病例罕见。