Department of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.
Eur J Immunol. 2010 Feb;40(2):437-42. doi: 10.1002/eji.200939699.
Chronic helminth infections induce T-cell hyporesponsiveness, which may affect immune responses to other pathogens or to vaccines. This study investigates the influence of Treg activity on proliferation and cytokine responses to BCG and Plasmodium falciparum-parasitized RBC in Indonesian schoolchildren. Geohelminth-infected children's in vitro T-cell proliferation to either BCG or pRBC was reduced compared to that of uninfected children. Although the frequency of CD4(+)CD25(hi)FOXP3(+) T cells was similar regardless of infection status, the suppressive activity differed between geohelminth-infected and geohelminth-uninfected groups: Ag-specific proliferative responses increased upon CD4(+)CD25(hi) T-cell depletion in geohelminth-infected subjects only. In addition, IFN-gamma production in response to both BCG and parasitized RBC was increased after removal of CD4(+)CD25(hi) T cells. These data demonstrate that geohelminth-associated Treg influence immune responses to bystander Ag of mycobacteria and plasmodia. Geohelminth-induced immune modulation may have important consequences for co-endemic infections and vaccine trials.
慢性寄生虫感染会诱导 T 细胞反应低下，这可能会影响对其他病原体或疫苗的免疫反应。本研究调查了 Treg 活性对印度尼西亚学童中 BCG 和疟原虫寄生 RBC 的增殖和细胞因子反应的影响。与未感染的儿童相比，感染土源性蠕虫的儿童对 BCG 或 pRBC 的体外 T 细胞增殖减少。尽管无论感染状态如何，CD4+CD25+hiFOXP3+T 细胞的频率相似，但土源性蠕虫感染和未感染组之间的抑制活性不同：仅在土源性蠕虫感染组中，CD4+CD25+hiT 细胞耗竭后，特异性增殖反应增加。此外，BCG 和寄生 RBC 反应的 IFN-γ产生在去除 CD4+CD25+hiT 细胞后增加。这些数据表明，土源性蠕虫相关的 Treg 影响对分枝杆菌和疟原虫旁观者抗原的免疫反应。土源性蠕虫诱导的免疫调节可能对共流行感染和疫苗试验有重要影响。
