Zhu Feifan, Liu Wenyi, Liu Tong, Shi Linpeng, Zheng Wenwen, Guan Fei, Lei Jiahui
Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Pathogens. 2022 Oct 8;11(10):1163. doi: 10.3390/pathogens11101163.
Vaccines are one of the most successful medical inventions to enable the eradication or control of common and fatal diseases. Environmental exposure of hosts, including helminth infections, plays an important role in immune responses to vaccines. Given that helminth infections are among the most common infectious diseases in the world, evaluating vaccine efficiency in helminth-infected populations may provide critical information for selecting optimal vaccination programs. Here, we reviewed the effects of helminth infections on vaccination and its underlying immunological mechanisms, based on findings from human studies and animal models. Moreover, the potential influence of helminth infections on SARS-CoV-2 vaccine was also discussed. Based on these findings, there is an urgent need for anthelmintic treatments to eliminate helminth suppressive impacts on vaccination effectiveness during implementing mass vaccination in parasite endemic areas.
疫苗是促成根除或控制常见致命疾病的最成功的医学发明之一。宿主的环境暴露，包括蠕虫感染，在对疫苗的免疫反应中起重要作用。鉴于蠕虫感染是世界上最常见的传染病之一，评估蠕虫感染人群的疫苗效力可能为选择最佳疫苗接种方案提供关键信息。在此，我们根据人体研究和动物模型的结果，综述了蠕虫感染对疫苗接种的影响及其潜在的免疫机制。此外，还讨论了蠕虫感染对SARS-CoV-2疫苗的潜在影响。基于这些发现，在寄生虫流行地区实施大规模疫苗接种期间，迫切需要进行驱虫治疗以消除蠕虫对疫苗效力的抑制作用。
