Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto-Daigaku-Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
J Pept Sci. 2010 Feb;16(2):110-4. doi: 10.1002/psc.1206.
A novel amphiphilic cyclic peptide composed of two beta-glucosamino acids and one trans-2-aminocyclohexylcarboxylic acid was synthesized and investigated on assembly formation. The cyclic tri-beta-peptide was self-assembled into rodlike crystals or nanofibers depending on preparative conditions. The rodlike crystals showed a layer spacing of 4.8 A along the long axis, and columnar spacings of 10.8 and 21.5 A by electron diffraction analysis along the short axis. The former confirms the columnar structure upon molecular stacking, and the latter indicates triple bundle formation of the columnar assemblies. Fourier transform infrared (FT-IR) measurement of the fibrous assembly showed formation of homogeneous hydrogen bonds among amide groups, also supporting the molecular stacking of cyclic beta-peptides. Straight nanofibers with uniform diameter were also uniquely obtained.
一种新型两亲性环肽由两个β-氨基葡萄糖和一个反式-2-氨基环己烷羧酸组成，研究了其组装形成。环三-β-肽可根据制备条件自组装成棒状晶体或纳米纤维。棒状晶体沿长轴显示出 4.8Å 的层间距，沿短轴通过电子衍射分析显示出 10.8 和 21.5Å 的柱状间距。前者证实了分子堆积时的柱状结构，后者表明柱状组装体的三束形成。纤维组装体的傅里叶变换红外（FT-IR）测量表明酰胺基团之间形成了均匀的氢键，也支持环β-肽的分子堆积。还独特地获得了具有均匀直径的直纳米纤维。
