Carpenter James W, Pollock Christal G, Koch David E, Hunter Robert P
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, USA.
J Zoo Wildl Med. 2009 Dec;40(4):601-6. doi: 10.1638/2007-0115.1.
The nonsteroidal anti-inflammatory drug (NSAID) meloxicam is a very popular anti-inflammatory, analgesic, and antipyretic agent used in veterinary medicine. To determine the pharmacokinetics of this NSAID in rabbits following a single dose and 10-day period of dosing, eight clinically normal, 8-mo-old New Zealand white rabbits (Oryctolagus cuniculus) were administered 0.2 mg/kg meloxicam p.o. daily. Pharmacokinetic analysis of the meloxicam was determined via noncompartmental analysis. After oral administration, mean +/- standard deviation values for area under the curve were 1.8 +/- 0.50 and 2.1 +/- 0.55 microg x h/ml, and maximum plasma concentrations were 0.17 +/- 0.06 and 0.24 +/- 0.07 microg/ml for Day 1 and Day 10, respectively. The half-life was approximately 8 hr. Administration of meloxicam at a dosage of 0.2 to 0.3 mg/kg p.o. every 24 hr is suggested. Although a higher dose may be required for optimum effects, this would require efficacy and safety studies in this species. Meloxicam administered at 0.2 mg/kg p.o. daily for 10 day was well tolerated by the rabbits.
非甾体抗炎药美洛昔康是兽医学中一种非常常用的抗炎、镇痛和解热药物。为了确定单次给药和连续给药10天后该非甾体抗炎药在兔体内的药代动力学，对8只临床正常、8月龄的新西兰白兔（穴兔）每日口服给予0.2mg/kg美洛昔康。通过非房室分析确定美洛昔康的药代动力学。口服给药后，第1天和第10天曲线下面积的平均值±标准差分别为1.8±0.50和2.1±0.55μg·h/ml，最大血浆浓度分别为0.17±0.06和0.24±0.07μg/ml。半衰期约为8小时。建议每24小时口服给予0.2至0.3mg/kg的美洛昔康。虽然可能需要更高剂量才能达到最佳效果，但这需要在该物种中进行疗效和安全性研究。每日口服给予0.2mg/kg美洛昔康，连续10天，兔对其耐受性良好。
