Kasparová D, Fait T
Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha.
Ceska Gynekol. 2009 Oct;74(5):360-5.
Review the literature regarding inherited thrombophilic states and early pregnancy loss.
Literary review.
Department of Gynekology and Obstetrics, 1st Faculty of Medicine, Charles University Prague.
Thrombotic risk is increased in normal pregnancy. This risk is further enhanced in women with congenital or aquired thrombophilia. As an adequate placental circulation is dependent on the normal balance procoagulant and anticoagulant mechanism, inherited thrombophilia may be associated with fetal loss. Literary review.
Placental thrombosis may be final common pathophysiologic pathway in most women with habitus abortions and repeated pregnancy wastage. Preliminary nonrandomized studies suggest a benefit for prophylaxis with unfractioned and low-molecular-weight heparin (LMWH), and prospective randomized trials are in progress to define whether LMWH is effective in preventive pregnancy loss and other gestational vascular complications in women with thrombophilia and previus fetal wastage.
回顾关于遗传性血栓形成倾向与早期妊娠丢失的文献。
文献综述。
布拉格查理大学医学院第一附属医院妇产科。
正常妊娠时血栓形成风险增加。先天性或后天性血栓形成倾向的女性这一风险会进一步升高。由于充足的胎盘循环依赖于促凝血和抗凝机制的正常平衡，遗传性血栓形成倾向可能与胎儿丢失有关。文献综述。
胎盘血栓形成可能是大多数习惯性流产和反复妊娠丢失女性最终共同的病理生理途径。初步的非随机研究表明，普通肝素和低分子量肝素（LMWH）预防有益，前瞻性随机试验正在进行，以确定LMWH对预防血栓形成倾向和既往有胎儿丢失史女性的妊娠丢失及其他妊娠血管并发症是否有效。
