Department of Clinical Pathology, Hasan Sadikin Hospital, Medical Faculty, Universitas Padjadjaran, Bandung, Indonesia.
J Infect Dis. 2010 Feb 15;201(4):553-7. doi: 10.1086/650311.
Animal studies have shown that the globally emerging Beijing genotype strains of Mycobacterium tuberculosis are more virulent than other strains. We examined whether Beijing strains increase treatment failure in a prospective cohort study in Indonesia. Among 818 tuberculosis cases, positive sputum culture results after 6 months of treatment were more common among patients infected with Beijing strains (33.4%) than among those infected with non-Beijing strains (relative risk, 1.94 [95% confidence interval, 1.26-3.00]), even after adjustment for differences in drug resistance. These data suggest that M. tuberculosis Beijing genotype strains have a higher capacity to withstand tuberculosis treatment, even in the absence of drug resistance.
动物研究表明，全球新兴的结核分枝杆菌北京基因型菌株比其他菌株更具毒力。我们在印度尼西亚的一项前瞻性队列研究中检验了北京基因型菌株是否会增加治疗失败的风险。在 818 例肺结核病例中，治疗 6 个月后痰培养阳性的患者中，感染北京基因型菌株的患者（33.4%）比感染非北京基因型菌株的患者（相对风险，1.94[95%置信区间，1.26-3.00]）更常见，即使在调整了耐药性差异后也是如此。这些数据表明，结核分枝杆菌北京基因型菌株具有更高的耐结核病治疗能力，即使不存在耐药性也是如此。
