Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Denmark.
Acta Ophthalmol. 2011 Dec;89(8):774-8. doi: 10.1111/j.1755-3768.2009.01832.x. Epub 2010 Jan 8.
To examine retinal electrophysiological function and retinal thickness in healthy eyes before and after hyperbaric oxygen (HBO) exposure.
The healthy eye in each of six subjects who underwent experimental HBO treatment for branch retinal vein occlusion in the fellow eye was examined using multifocal electroretinography (mfERG) and optical coherence tomography (OCT) at baseline and following a course of five consecutive daily sessions of exposure to HBO at 2.4 atmospheres of absolute pressure lasting 90 min each.
After HBO, P1 implicit times of the mfERG were significantly shorter than at baseline. The response was delayed, being undetectable on the day treatment concluded, whereas a 2.65% reduction in implicit time was seen 1 week later (p = 0.032). The P1 implicit time remained 2.49% shorter than at baseline 1 month after the end of the HBO sessions (p = 0.020). The bulk of the response to HBO was found in the foveal and parafoveal regions. No detectable change was seen in mfERG amplitudes or in the volume or thickness of the retina.
A mfERG component related to bipolar and Müller cell function was accelerated by a short intermittent exposure to HBO. The response developed after the end of the HBO exposure and lasted for at least 3 weeks, suggesting that it was prompted by the withdrawal of HBO rather than the onset and subsequent brief exposure to HBO.
观察高压氧（HBO）暴露前后健康眼的视网膜电生理功能和视网膜厚度。
对 6 例接受实验性 HBO 治疗对侧视网膜分支静脉阻塞患者的健康眼，分别在基线和 5 天连续每日 HBO 暴露（2.4 个大气压，每次 90 分钟）后，使用多焦视网膜电图（mfERG）和光学相干断层扫描（OCT）进行检查。
HBO 后，mfERG 的 P1 潜伏期明显短于基线。反应延迟，治疗结束当天无法检测到，而 1 周后潜伏期缩短了 2.65%（p=0.032）。HBO 结束后 1 个月，P1 潜伏期仍比基线短 2.49%（p=0.020）。HBO 的大部分反应发生在中心凹和旁中心凹区域。mfERG 幅度或视网膜体积或厚度均无明显变化。
短暂间歇性 HBO 暴露可加速与双极和 Müller 细胞功能相关的 mfERG 成分。反应发生在 HBO 暴露结束后，并持续至少 3 周，提示其是由 HBO 的撤出而不是 HBO 的起始和短暂暴露引起的。
