Department of Pediatric Gastroenterology, Hepatology and Nutrition, Başkent University Faculty of Medicine, Ankara, TurkeyObstetric and Children Hospital, Adana, TurkeyDepartment of Pediatric Hematology, Başkent University Faculty of Medicine, Ankara, Turkey.
Acta Paediatr. 2010 May;99(5):786-788. doi: 10.1111/j.1651-2227.2009.01669.x. Epub 2010 Jan 7.
Individuals with celiac disease (CD) are predisposed to a number of haematological abnormalities including anaemia secondary to malabsorption of iron, vitamin B12 or folate; anaemia of chronic disease and coagulopathy secondary to vitamin K deficiency. Correction of coagulopathy with vitamin K is necessary before endoscopic biopsy in patients with suspected CD. However, vitamin K causes haemolysis in glucose-6 phosphate-dehydrogenase deficiency.
When vitamin K administration becomes necessary for correction of coagulopathy in patients with CD; glucose-6 phosphate-dehydrogenase deficiency should be considered.
乳糜泻（CD）患者易发生多种血液学异常，包括铁、维生素 B12 或叶酸吸收不良引起的贫血；慢性疾病引起的贫血和维生素 K 缺乏引起的凝血功能障碍。在怀疑患有 CD 的患者进行内镜活检之前，需要用维生素 K 纠正凝血功能障碍。然而，维生素 K 会导致葡萄糖-6-磷酸脱氢酶缺乏症患者的溶血。
当 CD 患者需要用维生素 K 纠正凝血功能障碍时，应考虑葡萄糖-6-磷酸脱氢酶缺乏症。
