Department of Haematological Medicine, King's College Hospital NHS Trust, Denmark Hill, London, UK.
Br J Haematol. 2010 Apr;149(2):289-91. doi: 10.1111/j.1365-2141.2009.08062.x. Epub 2010 Jan 7.
Acute Human Parvovirus B19 (HPV B19) infection is the major cause of transient red cell aplasia (TRCA) and acute anaemia in patients with sickle cell disease (SCD). We report three cases of patients who developed nephrotic syndrome (NS) with chronic sequelae after initially presenting with HPV B19-associated TRCA. There was no correlation between evidence of HPV B19 infection and impaired renal function in our cohort of adult sickle cell patients. This is consistent with a view that although NS is potentially a rare complication of symptomatic acute HPV B19 infection, exposure to HPV B19 is not associated with an increased risk of renal disease.
急性人类细小病毒 B19（HPV B19）感染是导致镰状细胞病（SCD）患者出现短暂性红细胞再生障碍（TRCA）和急性贫血的主要原因。我们报告了三例最初表现为 HPV B19 相关 TRCA 的患者，其后发生了肾病综合征（NS）及慢性后遗症。在我们的成年镰状细胞病患者队列中，HPV B19 感染的证据与肾功能受损之间没有相关性。这与以下观点一致，即尽管 NS 是有症状的急性 HPV B19 感染的潜在罕见并发症，但接触 HPV B19 并不增加患肾病的风险。
