Krishnamurti Lakshmanan, Lanford Lizabeth, Munoz Ricardo
Division of Hematology/Oncology/BMT, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center Health System, Pittsburgh, Pennsylvania 15213, USA.
Pediatr Blood Cancer. 2007 Dec;49(7):1019-21. doi: 10.1002/pbc.20855.
Human parvovirus (HPV) B19, a common infection, frequently causes transient red cell aplasia in children with hemolytic anemia, such as sickle cell disease (SCD). It was considered to be a self-limited condition, easily treated with blood transfusion. However, acute splenic sequestration, acute chest syndrome, nephrotic syndrome, and stroke have been reported in SCD patients following HPV B19 infection. We report a 3-year-old child with SCD who developed fulminant myocarditis following HPV B19-related aplastic crisis. The diagnosis of myocarditis should be considered in a patient with hemolytic anemia with an infection with HPV B19 who develops signs of cardiopulmonary failure despite correction of anemia.
人细小病毒（HPV）B19是一种常见感染，常导致溶血性贫血患儿（如镰状细胞病[SCD]）出现短暂的红细胞再生障碍。它曾被认为是一种自限性疾病，通过输血易于治疗。然而，已有报告称HPV B19感染后的SCD患者会出现急性脾滞留、急性胸部综合征、肾病综合征和中风。我们报告了一名3岁的SCD患儿，在HPV B19相关的再生障碍危象后发生了暴发性心肌炎。对于患有溶血性贫血且感染了HPV B19的患者，即使贫血得到纠正但出现心肺功能衰竭体征时，应考虑心肌炎的诊断。
