Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, 75390-9046, USA.
Mol Cell. 2009 Dec 25;36(6):922-3. doi: 10.1016/j.molcel.2009.12.005.
In this issue of Molecular Cell, Strisovsky et al. (2009) identify a sequence motif underlying cleavage site specificity for the rhomboid proteases. This sheds light on potential mechanisms by which intramembrane-cleaving proteases cleave their substrates.
在本期的《分子细胞》中,Strisovsky 等人(2009)确定了一个序列基序,该基序是扁形虫蛋白酶切割位点特异性的基础。这揭示了跨膜切割蛋白酶切割其底物的潜在机制。