Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.
Clin Chim Acta. 2010 Apr 2;411(7-8):500-4. doi: 10.1016/j.cca.2009.12.025. Epub 2010 Jan 12.
Haptoglobin polymorphism generates three common human genotypes: Hp1-1, Hp2-1 and Hp2-2. Among subjects with diabetes, Hp2-2 is associated with an elevated risk to develop cardiovascular disease. The impact of haptoglobin genotype on subclinical carotid atherosclerosis is not known. We hypothesized that Hp2-2 was associated with increased occurrence of carotid atherosclerosis in subjects with diabetes.
We studied a population-based sample of 64-year old women with diabetes (n=226), either established diabetes known before study entry (n=116) or new diabetes detected at study screening (n=110). Haptoglobin genotype was determined by PCR. Carotid atherosclerosis was assessed by ultrasound imaging.
In the entire diabetes cohort, no differences were observed in carotid intima-media thickness (IMT) or plaque prevalence between the genotype groups. However, among those with established diabetes, Hp2-2 was associated with higher plaque prevalence and larger carotid IMT compared with the Hp2-1 and Hp1-1 genotypes. Common cardiovascular risk factors did not differ between the genotype groups.
The Hp2-2 genotype was associated with increased occurrence of subclinical carotid atherosclerosis in 64-year old women with established diabetes. This association was not explained by traditional risk factors for cardiovascular disease. These results extend previous observations that Hp2-2 is associated with clinical cardiovascular disease in diabetes.
触珠蛋白多态性产生三种常见的人类基因型：Hp1-1、Hp2-1 和 Hp2-2。在糖尿病患者中，Hp2-2 与发生心血管疾病的风险增加相关。触珠蛋白基因型对亚临床颈动脉粥样硬化的影响尚不清楚。我们假设 Hp2-2 与糖尿病患者颈动脉粥样硬化的发生增加有关。
我们研究了一个基于人群的 64 岁女性糖尿病样本（n=226），包括研究前已知的已确诊糖尿病（n=116）或研究筛查时新诊断的糖尿病（n=110）。触珠蛋白基因型通过 PCR 确定。颈动脉粥样硬化通过超声成像评估。
在整个糖尿病队列中，基因型组之间的颈动脉内膜中层厚度（IMT）或斑块患病率没有差异。然而，在已确诊的糖尿病患者中，与 Hp2-1 和 Hp1-1 基因型相比，Hp2-2 与更高的斑块患病率和更大的颈动脉 IMT 相关。常见心血管危险因素在基因型组之间没有差异。
在 64 岁患有已确诊糖尿病的女性中，Hp2-2 基因型与亚临床颈动脉粥样硬化的发生增加有关。这种关联不能用心血管疾病的传统危险因素来解释。这些结果扩展了之前的观察结果，即 Hp2-2 与糖尿病患者的临床心血管疾病相关。
