Dalan Rinkoo, Liew Huiling, Goh Liuh Ling, Gao Xiao, Chew Daniel Ek, Boehm Bernhard O, Leow Melvin Khee Shing
Endocrinology Department, Tan Tock Seng Hospital, Singapore Metabolic Medicine Research Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
Endocrinology Department, Tan Tock Seng Hospital, Singapore.
Diab Vasc Dis Res. 2016 Sep;13(5):373-6. doi: 10.1177/1479164116645247. Epub 2016 May 16.
The haptoglobin 2-2 genotype is associated with atherosclerosis in type 2 diabetes mellitus. We examined the associations of the haptoglobin 2-2 genotype with C-reactive protein (high-sensitivity C-reactive protein) and carotid artery intima-media thickness, adjusting for age, gender, ethnicity, type 2 diabetes mellitus, smoking status, body mass index, blood pressure, glycated haemoglobin, non-high-density lipoprotein cholesterol and medications via logistic multivariate regression in 200 subjects (160 type 2 diabetes mellitus versus 40 healthy individuals). The prevalence of the haptoglobin 2-2 genotype was 58% (115/200), higher in the Indians than in Chinese (72% versus 45%, p = 0.001). Multivariate analysis showed that the haptoglobin 2-2 genotype was associated with high-sensitivity C-reactive protein [mean: 3.5 ± 3.9 versus 2.2 ± 2.6 mg/L (non-haptoglobin 2-2), p < 0.001], haptoglobin concentration [mean: 116.9 ± 54.4.0 versus 147.2 ± 54.5 mg/dL (non-haptoglobin 2-2), p < 0.001] and average carotid artery intima-media thickness (multiplied by 10) [6.15 ± 1.22 versus 5.98 ± 1.20 mm (non-haptoglobin 2-2), p = 0.013]. This pilot study shows an association of the haptoglobin 2-2 genotype with low-grade inflammation, haptoglobin concentration and carotid artery intima-media thickness in multi-ethnic Singapore.
触珠蛋白2-2基因型与2型糖尿病患者的动脉粥样硬化有关。我们在200名受试者（160名2型糖尿病患者与40名健康个体）中，通过逻辑多元回归分析，研究了触珠蛋白2-2基因型与C反应蛋白（高敏C反应蛋白）及颈动脉内膜中层厚度之间的关联，并对年龄、性别、种族、2型糖尿病、吸烟状况、体重指数、血压、糖化血红蛋白、非高密度脂蛋白胆固醇和药物进行了校正。触珠蛋白2-2基因型的患病率为58%（115/200），印度人的患病率高于中国人（72%对45%，p = 0.001）。多变量分析显示，触珠蛋白2-2基因型与高敏C反应蛋白[平均值：3.5±3.9对2.2±2.6mg/L（非触珠蛋白2-2），p<0.001]、触珠蛋白浓度[平均值：116.9±54.4.0对147.2±54.5mg/dL（非触珠蛋白2-2），p<0.001]以及平均颈动脉内膜中层厚度（乘以10）[6.15±1.22对5.98±1.20mm（非触珠蛋白2-2），p = 0.013]有关。这项初步研究表明，在多民族的新加坡，触珠蛋白2-2基因型与低度炎症、触珠蛋白浓度及颈动脉内膜中层厚度有关。
