具有双重 5-HT1A 受体和 5-羟色胺转运体亲和力的新型苯并呋喃衍生物。
Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity.
机构信息
Chemical Sciences, Wyeth Research, Pearl River, NY 10965, United States.
出版信息
Bioorg Med Chem Lett. 2010 Feb 1;20(3):824-7. doi: 10.1016/j.bmcl.2009.12.093. Epub 2010 Jan 4.
PMID:20064720
Abstract
Several benzofuran derivatives linked to a 3-indoletetrahydropyridine through an alkyl chain were prepared and evaluated for serotonin transporter and 5-HT(1A) receptor affinities. Their design, synthesis and structure-activity relationships are described.
摘要
几种通过烷基链连接到 3-吲哚四氢吡啶上的苯并呋喃衍生物被制备出来，并对其 5-羟色胺转运体和 5-HT（1A）受体亲和力进行了评估。描述了它们的设计、合成和构效关系。
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