抗癌铂配合物作为水相介质中催化的非无辜化合物。
Anticancer platinum complexes as non-innocent compounds for catalysis in aqueous media.
机构信息
Departamento de Química Orgánica (C-I), Universidad Autónoma de Madrid, 28049-Madrid, Spain.
出版信息
Chem Commun (Camb). 2010 Jan 21;46(3):454-6. doi: 10.1039/b917758b. Epub 2009 Nov 11.
DOI:10.1039/b917758b
PMID:20066323
Abstract
An efficient cyclization of alkyne-acids to enol-lactones catalyzed by anticancer platinum(II) and platinum(IV) compounds is described. These compounds are not only DNA-binding complexes; they can also catalyze reactions in solvents such as acetone, methanol, water or blood plasma.
摘要
描述了一种由抗癌铂(II)和铂(IV)化合物催化的炔酸到烯醇内酯的高效环化反应。这些化合物不仅是 DNA 结合复合物；它们还可以在丙酮、甲醇、水或血浆等溶剂中催化反应。
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