使用烯基磺酰胺、烯基氨基甲酸酯或烯酰胺作为亲核试剂，铂（II）催化形成季碳中心的环化反应。
Platinum(II)-catalyzed cyclizations forming quaternary carbon centers, using enesulfonamides, enecarbamates, or enamides as nucleophiles.
作者信息
Harrison Tyler J, Patrick Brian O, Dake Gregory R
机构信息
Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1.
出版信息
Org Lett. 2007 Jan 18;9(2):367-70. doi: 10.1021/ol062939g.
PMID:17217306
Abstract
Cyclic enesulfonamides, enecarbamates, or enamides tethered to an alkyne cyclize readily with use of platinum(II) chloride. This reaction generates quaternary-substituted carbon centers within simple spiro-fused or more complex tri- and tetracyclic heterocyclic ring systems. The yields for this process range from 50% to 83%. [reaction: see text].
摘要
与炔烃相连的环状烯基磺酰胺、烯基氨基甲酸酯或烯酰胺在使用氯化铂（II）时很容易发生环化反应。该反应在简单的螺稠合或更复杂的三环和四环杂环系统中生成季碳取代中心。该过程的产率为50%至83%。[反应：见正文]
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