Biomaterials Center, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
Chemistry. 2010 Feb 8;16(6):1786-92. doi: 10.1002/chem.200902534.
In this article, we show that the redox properties of the regulatory peptide L-glutathione are affected by the presence of nickel oxide impurities within single-walled carbon nanotubes (SWCNTs). Glutathione is a powerful antioxidant that protects cells from oxidative stress by removing free radicals and peroxides. We show that the L-cysteine moiety in L-glutathione is responsible for the susceptibility to oxidation by metallic impurities present in the carbon nanotubes. These results have great significance for assessing the toxicity of carbon-nanotube materials. The SWCNTs were characterized by Raman spectroscopy, high-resolution X-ray photoelectron spectroscopy, transmission electron microscopy, and energy dispersive X-ray spectroscopy.
在本文中，我们表明，调节肽 L-谷胱甘肽的氧化还原性质受到单壁碳纳米管（SWCNTs）中存在的氧化镍杂质的影响。谷胱甘肽是一种强大的抗氧化剂，可通过清除自由基和过氧化物来保护细胞免受氧化应激。我们表明，L-谷胱甘肽中的 L-半胱氨酸部分负责对存在于碳纳米管中的金属杂质的易氧化性。这些结果对于评估碳纳米管材料的毒性具有重要意义。SWCNTs 通过拉曼光谱、高分辨率 X 射线光电子能谱、透射电子显微镜和能量色散 X 射线能谱进行了表征。
