Departamento de Fisiología, Farmacología y Toxicología, Facultad de Ciencias de la Salud, Universidad CEU Cardenal Herrera, 46113 Moncada, Spain.
Drug Deliv. 2010 Feb;17(2):83-91. doi: 10.3109/10717540903509019.
The aim of the present study was to develop a sumatriptan succinate transdermal system for applying migraine treatments efficiently and easily. For this system polyvinyl alcohol was employed as a matrix and Azone((R)) was added as a permeability enhancer. The physical characteristics, mechanical properties, and in vivo bioadhesion of the systems were evaluated, as was in vitro permeation across porcine skin. A uniform distribution of the drug in the matrix was observed, and moisture uptake values were constant. With regard to mechanical parameters, occlusive layer inclusion made the system more resistant, and no significant differences were detected with respect to other systems. Although Azone((R)) reduced the bioadhesivity of the systems, adherence to skin was maintained 24 h after application. Permeation studies showed that the systems formulated with Azone((R)) provided the highest permeability profiles for sumatriptan succinate.
本研究旨在开发一种曲坦琥珀酸透皮系统，以便高效、简便地治疗偏头痛。该系统以聚乙烯醇为基质，加入氮酮作为渗透促进剂。对系统的物理特性、机械性能和体内生物黏附性以及体外透皮进行了评价。药物在基质中分布均匀，吸湿性值保持稳定。就机械参数而言，加入封闭层使系统更具阻力，但与其他系统相比，没有检测到显著差异。尽管氮酮降低了系统的生物黏附性，但在应用 24 小时后仍能保持对皮肤的黏附。渗透研究表明，含有氮酮的系统为琥珀酸舒马曲普坦提供了最高的渗透特性。
